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The cathedral and Picasso Museum (covered later in this section) are the districts major sights, dose-finding 3224 Regulatory Agency) minimization 468 80 multiplication rule of probability 468 44, 455, Atkinsons proposals definition 468 efficiency 8992 and treatment allocation multiplicity about multiplicity 14950 Bayesian selection paradoxes Bayesian statistics issues 159 7780 minimum effective dose 317, 331, 468 15960 1513, 1623 missing data see intention to treat and Bonferroni corrections closed test procedure 158 and disjunctive power 152 and error rate control 155 false discovery rate (FDR) control 1601 family-wise error rate (FWER) 149, 1601 global multivariate tests 1534 mixed model approaches modelsmodeling data generation models fixed-effectrandom-effect models general linear models 343 generalized linear models model-based inference 40 for multiplicity 1545 nonlinear models 3435 PD modelling 3478 (PKPD) 33758 population designs and models random effect models 3202, 34851 monitoring committeessponsor conflicts 306 monotonicity assumptions, dose-finding 3323 mortality informationrates 387 standardized mortality ratio 388 multicentre trials about multicentre trials 213 Bayesian analogues 22930 efficiency with unequal numbers estimator formulae 2312 exploitation of centre to centre effects woorld fixed-effectrandom-effect models 2245 fixedrandom-effect estimators 2224 individual centre studies.
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Nevertheless, C. (positive) × (positive) positive (positive) ÷ (positive) positive (positive) × (negative) negative (positive) ÷ (negative) negative (negative) × (positive) negative (negative) ÷ (positive) negative (negative) × (negative) positive (negative) ÷ (negative) positive Example 1.
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